Melatonin

Route: Serotonin (5-hydroxytryptamine) → N-Acetylserotonin → Melatonin

Serotonin N-acetyltransferase moves the acetyl group of acetyl-CoA onto the amino group of serotonin and gives N-acetylserotonin. Acetylserotonin O-methyltransferase then transfers a methyl group from S-adenosylmethionine to the hydroxyl group on the ring and gives melatonin. The acetyltransferase controls the night and day rhythm of melatonin production in the pineal gland. Melatonin helps maintain the natural sleep-wake cycle.

Practice this pathway All pathways

Steps

Molecules

Build any of these from its atoms.

• Serotonin (5-hydroxytryptamine) Build it
• N-Acetylserotonin Build it
• Melatonin Build it

Enzyme names and EC numbers are those used on the interactive board. Checked against sources: see the claim table in the repository (tools/pathway_data/checks).