One step: thymidine kinase adds a phosphate from ATP
Route: Thymidine → Thymidine monophosphate
Thymidine kinase moves a phosphate from ATP to the 5' hydroxyl of thymidine, which gives dTMP. This skips the ribonucleotide reductase and thymidylate synthase steps of the de novo pathway. Thymidine kinase 1 is a cell cycle regulated enzyme with peak expression in S phase, when DNA is copied.
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| Step | Enzyme | EC | In | Out |
|---|---|---|---|---|
| 1 | Thymidine kinase | 2.7.1.21 | ATP | ADP |
Enzyme names and EC numbers are those used on the interactive board. Checked against sources: see the claim table in the repository (tools/pathway_data/checks).