Oxaloacetate to aspartate in one step: a transaminase moves the amino group from glutamate
Route: Oxaloacetate + Glutamate → Aspartate + α-KG
The same kind of reaction as the alanine pathway, on a Krebs cycle compound instead of pyruvate. Oxaloacetate takes the amino group of glutamate and becomes aspartate; glutamate becomes α-ketoglutarate. Aspartate gives its nitrogen to the urea cycle (in argininosuccinate) and its carbon skeleton to threonine, methionine and lysine in bacteria such as E. coli. Isoleucine comes later, from threonine.
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| Step | Enzyme | EC | In | Out |
|---|---|---|---|---|
| 1 | Aspartate aminotransferase | 2.6.1.1 |
Enzyme names and EC numbers are those used on the interactive board. Checked against sources: see the claim table in the repository (tools/pathway_data/checks).